ProSynbiotic, a probiotic for everyday microbial support, is a synergistic blend of 4 probiotic microbes and a prebiotic fiber to support overall intestinal health.*
- Contains inulin which is used by probiotic bacteria as food
- Supports a healthy gut microbial environment*
- Supports normal bowel regularity*
- Supports the body's natural immune system response function*
Importance of Everyday Probiotic Support
“Good” microbes we consume from the diet — also known as probiotics — can play a critical role in a number of human health aspects. When consumed in clinically researched amounts, probiotics can provide wellness benefits, which include healthy immune system support and gut composition. They live amongst us as part of our microbiota, many of these are introduced to our bodies from the environment.
Probiotics have different target uses depending on species, strain, and added components such as prebiotics. Unique probiotic actions are demonstrated in a narrow number of strains in clinical studies.[4] Probiotics can also be combined with prebiotic to create a product termed “synbiotic” that brings the best both these components have to offer [8].
How Prebiotic Inulin Supports Gut Health
The prebiotic fiber in ProSynbiotic, inulin, is a naturally occurring storage polysaccharide in some plants. When consumed by people, it can selectively stimulate growth and/or activity of several health-stimulating intestinal bacteria[6]. It also cannot be digested by human intestinal enzymes; it passes the mouth, stomach, and small intestine without being metabolized. [5] This is important because, by resisting digestion, it is able to reach the large intestine where it can positively interact with microbes.
How Lactic Acid Bacteria (LAB) Support the Gut Microbial Environment
The LAB in ProSynbiotic include: Bifidobacterium lactis, Lactobacillus acidophilus, and Lactobacillus paracasei. While lactic acid bacteria (LAB) make up a relatively small fraction of the native human gut microbiota, they are widely held as excellent probiotics because they can benefit the gut microbial environment through multiple mechanisms. [9, 10]
B. lactis is a bacterium found in the colon. In a study that looked at 4 weeks of supplementation with 1 billion CFU/d of Bifidobacterium lactis, it was shown to support normal bowel regularity [14].
L. acidophilus is a bacterium found in the intestine where it ferments glucose into lactic and acetic acids[15]. These substances make the gut environment more acidic and help balance the microbiome.
L. paracasei is a bacterium found in the gut where it produces lactic and acetic acid. Some strains have been shown to break down prebiotics such as inulin to produce SCFAs.
How Probiotic Yeast Supports Healthy Immune System Response
S. boulardii is a probiotic yeast that can support proper intestinal permeability. In recent studies, support for proper intestinal permeability was observed in patients given Saccharomyces boulardii at a dose of 1.6 × 109 CFU/d for 4 months[16, 17]. Additionally, oral intake of S. boulardii has also been associated with positive microbiome/immune system benefits based on microbiome composition[18].
ProSynbiotic includes two billion CFU of S. boulardii per serving, consistent with evidence that supports a potentially beneficial effect on immune system response function and supporting normal bowel regularity. [14, 16-18].
Frequently Asked Questions
A synbiotic is a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host. We include with our formulation a prebiotic that comes from chicory root that is known to deliver fermentable energy to bacteria since our bodies don’t possess the ability to break down that material.
Taking probiotics 30 minutes before a meal or with food can minimize the acid that is acquired while the probiotics are moving through the stomach helping to further increase survival.
Yes, but note that these are live and active cultures so when they are added to foods with available water the microbes can begin to grow and ferment material. The capsule itself can have some impact on the survival of the probiotics, but these species are all resistant to acid and bile making them ideal to be consumed to make it to the GI intact
Not necessarily, the daily dose is important. For ProSynbiotic our base recommendation is that the serving would be taken all at once.
All of the probiotics are acid tolerant so they should be consumable whenever is convenient, but the more neutral pH may have some ability to increase survivability therefore we could recommend 30 minutes before acid stimulation or introduction by food or supplement (like Zypan).
References:
1. Kumar, M., et al., Chapter 6 - Probiotics and Prebiotics for Promoting Health: Through Gut Microbiota, in Probiotics, Prebiotics, and Synbiotics, R.R. Watson and V.R. Preedy, Editors. 2016, Academic Press. p. 75-85.
2. Bäckhed, F., et al., Host-Bacterial Mutualism in the Human Intestine. Science, 2005. 307(5717): p. 1915-1920.
3. Oelschlaeger, T.A., Mechanisms of probiotic actions–a review. International journal of medical microbiology, 2010. 300(1): p. 57-62.
4. Dudek-Wicher, R., et al., Clinical Trials of Probiotic Strains in Selected Disease Entities. Int J Microbiol, 2020. 2020: p. 8854119.
5. Niness, K.R., Inulin and Oligofructose: What Are They? The Journal of Nutrition, 1999. 129(7): p. 1402S-1406S.
6. Francino, M., Antibiotics and the human gut microbiome: dysbioses and accumulation of resistances. Frontiers in microbiology, 2016: p. 1543.
7. Peng, M. and D. Biswas, Short chain and polyunsaturated fatty acids in host gut health and foodborne bacterial pathogen inhibition. Critical reviews in food science and nutrition, 2017. 57(18): p. 3987-4002.
8. Ndagijimana, M., et al., Effect of a synbiotic food consumption on human gut metabolic profiles evaluated by 1H Nuclear Magnetic Resonance spectroscopy. International Journal of Food Microbiology, 2009. 134(1): p. 147-153.
9. Walter, J., Ecological role of lactobacilli in the gastrointestinal tract: implications for fundamental and biomedical research. Applied and environmental microbiology, 2008. 74(16): p. 4985-4996.
10. Salminen, S.J., M. Gueimonde, and E. Isolauri, Probiotics That Modify Disease Risk. The Journal of Nutrition, 2005. 135(5): p. 1294-1298.
11. Arboleya, S., et al., Gut Bifidobacteria Populations in Human Health and Aging. Frontiers in Microbiology, 2016. 7(1204).
12. Bian, G., et al., The Gut Microbiota of Healthy Aged Chinese Is Similar to That of the Healthy Young. mSphere, 2017. 2(5): p. e00327-17.
13. Fukuda, S., et al., Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature, 2011. 469(7331): p. 543.
14. Eskesen, D., et al., Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial. Br J Nutr, 2015. 114(10): p. 1638-46.
15. Salminen, S. and A. Von Wright, Lactic acid bacteria: microbiological and functional aspects. 2004: CRC Press.
16. Garcia Vilela, E., et al., Influence of Saccharomyces boulardii on the intestinal permeability of patients with Crohn's disease in remission. Scandinavian journal of gastroenterology, 2008. 43(7): p. 842-848.
Suggested Use:
Three capsules per day, or as directed. Store in a cool, dry place.
Please consult the product packaging label for the most accurate product information.
Warnings:
If pregnant or nursing, or have any health condition, consult your health care professional before using this product. Keep out of reach of children.
Nutrients & Ingredients
Nutrients & Ingredients – Each Serving Size (3 capsules) contains: Calories 5, Total Carbohydrate 1 g. Proprietary Blend 1,337 mg: Inulin (chicory root fiber), Saccharomyces boulardii (500 mg), Lactobacillus acidophilus, Lactobacillus paracasei, and Bifidobacterium animalis subsp. lactis. Other Ingredients: Cellulose, water, and calcium stearate.
* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.